From April to October 1942, the HMCS Regina (K 234) (LtCdr R.S. Kelly) served as convoy escort operating from Halifax and New York. She rescued 25 survivors from the Alexander Macomb, which had been sunk by U-215 (Hoeckner) in convoy BX-27 on 3 July and landed them in Halifax.
In November 1942, the HMCS Regina (K 234) (LtCdr Harry Freeland DSO) took part in Operation Torch the landings in North Africa and later joined the Gibraltar Escort Force. During the night of 9 Feb 1943, the corvette attacked the Italian submarine Avorio while escorting two stragglers from a convoy to Bone, Algeria and forced her to surface. It was then unsuccessfully tried to tow the badly damaged submarine to Bone, but she foundered.

In April 1943, she returned to Canada with convoy ON-174 for a short refit and was then operated again with the Western Escort Force from Halifax, St.Johns and New York. After a long refit from June 1943 to February 1944, the HMCS Regina (K 234) (Lt J.W. Radford) was transferred to the Escort Group C1 of the Mid-Ocean Escort Force with convoy SC-154.
In June 1944, the corvette took part in Operation Neptune", the naval part of the Invasion in the Normandy. On 6 June, her first duty was to escort the convoy EBM-2 from Milford Haven, Wales to the Normandy and served thereafter as escort for several convoys or individual ships and was also assigned to anti-submarine patrols.

The Battle Honours of HMCS Regina (K 234): Atlantic 1942-1944, Mediterranean 1943, English Channel 1944, Normandy 1944

At 21.27 hours on 8 Aug 1944 the Ezra Weston in convoy EBC-66 was hit by one torpedo from U-667 about eight miles off Trevose Head, Cornwall. The sole escort of convoy, HMCS Regina (K 234) (Lt J.W. Radford, RCNR) turned and slowed down to pick up survivors, thinking that the merchant had been mined. The U-boat fired a Gnat at the corvette, which blew up and sank within 30 seconds. One officer and 27 men were lost. The commander and 65 crew members were picked up by the British armed trawler HMS Jaques Morgand and the British landing ship HMS LCT-644 (SLt L.G. Read), but two men died of injuries before the vessel reached Padstow, Cornwall.