At 17.05 hours on 1 Dec 1942, U-375 fired a spread of four torpedoes at HMS Manxman (M 70) (Capt R.K. Dickson, DSO, RN) identified as a London class cruiser and heard two hits after 51 seconds despite the fact that the British ship was zigzagging at 21 knots. Two additional torpedoes fired at 17.41 and 18.42 hours missed. The cruiser was hit on the port side and flooding soon caused a list of 12° and disabled the ship. She was initially taken in tow by HMS Pathfinder (G 10) (Cdr E.A. Gibbs, DSO and Bar, RN), escorted by HMS Eskimo (G 75) (Capt J.W.M. Eaton, DSC, DSO, RN). Later towed by HMS Restive (W 39) to Mers-el-Kebir, arriving on 2 December. Later that month towed to Gibraltar for temporary repairs. In June 1943 left Gibraltar under tow by HMS Bustler (W 72), arriving on 8 July at Newcastle-upon-Tyne for permanent repairs that took almost two years. She returned to service in April 1945, joining the British Pacific fleet.