Germans lost many U-boats to the Allied submarine forces during 1939-1945. Several of those were lost with all hands. British submarines were the busiest with 13 kills. 4 U-boats were sunk in the Far East while they served as a part of the Monsun boats there and 5 more were sunk in the Mediterranean sea.
The war at sea was only 3 months old when Germany lost its first U-boat to the British submarine arm when HMS Salmon sank the U-36 outside Kristiansund in Norway.
The U-boats would be lost at a steady rate the entire war with the last one, U-183, being sunk by the USS Besugo on April 23, 1945, only 2 weeks before the German surrender.
| Date | Boat | Type | Dead |
| 4 Dec, 1939 | U-36 * | VIIA | 40 |
| 20 Aug, 1940 | U-51 * | VIIB | 43 |
| 25 Feb, 1940 | U-63 | IIC | 1 |
| 28 Nov, 1941 | U-95 | VIIC | 35 |
| 10 Aug, 1941 | U-144 * | IID | 28 |
| 6 Oct, 1944 | U-168 | IXC/40 | 23 |
| 23 Apr, 1945 | U-183 | IXC/40 | 54 |
| 21 Jan, 1943 | U-301 | VIIC | 45 |
| 21 May, 1943 | U-303 | VIIC | 20 |
| 4 Jun, 1943 | U-308 * | VIIC | 44 |
| 3 Aug, 1942 | U-335 | VIIC | 43 |
| 12 Jan, 1942 | U-374 | VIIC | 42 |
| 30 Mar, 1943 | U-416 | VIIC | 36 |
| 12 Apr, 1945 | U-486 * | VIIC | 48 |
| 9 Nov, 1944 | U-537 * | IXC/40 | 58 |
| 28 Aug, 1943 | U-639 * | VIIC | 47 |
| 7 Apr, 1943 | U-644 * | VIIC | 45 |
| 11 Nov, 1944 | U-771 * | VIIC | 51 |
| 23 Sep, 1944 | U-859 | IXD2 | 47 |
| 9 Feb, 1945 | U-864 * | IXD2 | 73 |
| 19 Apr, 1944 | U-974 | VIIC | 42 |
| 15 Jun, 1944 | U-987 * | VIIC | 53 |
22 boats (1046 total crews, 918 dead - 128 survivors).
* means the boat was sunk with all hands.


