4 4.7" guns (4x1)
8 .5" AA (2x4)
8 21" torpedo tubes (2x4) 

The specifications as listed above are for the 'normal' E-class destroyers. HMS Exmouth was fitted as flotilla leader and had some different specifications;
Displacement: 1495 BRT
Complement: 175 men
Lenght: 343 feet (oa)
Armament:
5 4.7" guns (5x1)
8 .5" AA (2x4)
8 21" torpedo tubes (2x4)
Speed: 36.75 knots
Power: 38000 HP
With the E-class the Admiralty dicided to revert to the enlarged flotilla leader with extra speed and armament based on the A-class leader HMS Codrington.

The E-class were fitted with .5" AA machine guns for Anti-Aircraft defence. These machine guns were not very useful. This was realised as early as 1932 by the Admiralty. Nevertheless the E-class and later destroyer classes were fitted with these machine guns. Also the lack of a good AA director had been realised but when the Second World War broke out little had been undertaken to solve this problem. The 4.7" guns were on new mountings allowing 40° elevation compared to 30° in the earlier classes.

HMS Esk and HMS Express were designed to be modified in 24 hours to the minelaying role. This involved removing of 'A' and 'Y' 4.7" guns and all the torpedo tubes and the installation of mine rails along the upper deck. They could carry 60 mines. 

E class ships hit by U-boats (1)